Calendar

Keep up to date with the latest events around the country.

Nov
30
Tue
Zooming in on Diabetes Journal Club November 30, 2021
Nov 30 @ 12:00 pm – 1:00 pm

Zooming in on Diabetes November 30 at 12:00 pm

Ms. Samantha Mar, Graduate Student – MSc program, Lynn Lab, BC Women’s and Children’s Hospital

Presentation Information

Title of Work In Progress: Characterizing the role of gene regulator Med15 in pancreatic alpha cells

About Zooming in on Diabetes Journal Club

It is a joint initiative across the University of British Columbia campuses including the Life Sciences Centre and the BC Children’s Hospital.

This Journal Club is designed for trainees to develop skills in critical evaluation of recent articles in the scientific literature related to diabetes research.

The intended audience are academic research trainees and faculty involved in diabetes research in British Columbia, Canada.

The journal club is held on Tuesdays and Thursdays via ZOOM.

Type 2 Diabetes and Indigenous Peoples – Supporting a Culturally-Safe and Self-Determined Journey  @ virtual event
Nov 30 @ 1:00 pm – 2:00 pm
Type 2 Diabetes and Indigenous Peoples - Supporting a Culturally-Safe and Self-Determined Journey  @ virtual event

Join the BCDRN for a special presentation on diabetes and Indigenous Peoples. A panel of experts will share their personal and professional experience navigating diabetes through an Indigenous lens. The event will be held virtually in Zoom. Register in advance to attend.

Panelists:

Jessica Guss Manager of Cultural Safety & Humility with the First Nations Health Authority

Rebecca Sovdi, Certified Diabetes Educator with IDEA (Inspiring Diabetes Empowerment Associates)

Barbara MacDonald, Certified Diabetes Educator with IDEA (Inspiring Diabetes Empowerment Associates)

 

 

Dec
2
Thu
Zooming in on Diabetes Journal Club December 2, 2021
Dec 2 @ 9:00 am – 10:00 am

Zooming in on Diabetes Thursday, December 2, 2021 at 09:00 am (PST) 

Presenter: Mikky Atser, Graduate Student – MSc program, Johnson Lab, Life Sciences Institute, University of British Columbia (Vancouver)

Title: 

Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect

Abstract:   

Pharmacological activation of the glycolytic enzyme PKM2 or expression of the constitutively active PKM1 isoform in cancer cells results in decreased lactate production, a phenomenon known as the PKM2 paradox in the Warburg effect. Here we show that oxaloacetate (OAA) is a competitive inhibitor of human lactate dehydrogenase A (LDHA) and that elevated PKM2 activ- ity increases de novo synthesis of OAA through glutaminolysis, thereby inhibiting LDHA in cancer cells. We also show that replacement of human LDHA with rabbit LDHA, which is relatively resistant to OAA inhibition, eliminated the paradoxical correlation between the elevated PKM2 activity and the decreased lactate concentration in cancer cells treated with a PKM2 activator. Furthermore, rabbit LDHA-expressing tumours, compared to human LDHA-expressing tumours in mice, displayed resistance to the PKM2 activator. These findings describe a mechanistic explanation for the PKM2 paradox by showing that OAA accumulates and inhibits LDHA following PKM2 activation.

PMID: 34226744

URL link to publication source: https://pubmed.ncbi.nlm.nih.gov/34226744/

“Zooming in on Diabetes” is a virtual journal club and was launched in March 2020.

It is a joint initiative across the University of British Columbia campuses including the Life Sciences Centre and the BC Children’s Hospital.

This Journal Club is designed for trainees to develop skills in critical evaluation of recent articles in the scientific literature related to diabetes research.

The intended audience are academic research trainees and faculty involved in diabetes research in British Columbia, Canada.

The journal club is held on Tuesdays and Thursdays via ZOOM.

Dec
6
Mon
International Diabetes Federation Congress 2021 Bangkok Thailand @ Bangkok Thailand
Dec 6 – Dec 9 all day

Feb
15
Tue
Alberta British Columbia Islet Workshop 2022
Feb 15 @ 7:30 pm – Feb 18 @ 9:30 am
Alberta British Columbia Islet Workshop 2022

Visit event website for latest information, to submit an abstract and to register.

 

 

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