Calendar

Keep up to date with the latest events around the country.

Apr
20
Tue
Zooming in on Diabetes Journal Club April 20, 2021
Apr 20 @ 12:00 pm – 1:00 pm

Zooming in on Diabetes Tuesday, April 20, 2021 at 12:00 pm (PST)

Presenter:  Raelyn Gallant, Graduate Student – MSc program, Verchere Lab BC Women’s and Children’s Hospital

Title: Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages

Abstract:  

Both innate and adaptive immune cells are critical players in autoimmune destruction of insulin-producing β cells in type 1 diabetes. However, the early pathogenic events triggering the recruitment and activation of innate immune cells in islets remain obscure. Here we show that circulating fatty acid binding protein 4 (FABP4) level was significantly elevated in patients with type 1 diabetes and their first-degree relatives and positively correlated with the titers of several islet autoantibodies. In nonobese diabetic (NOD) mice, increased FABP4 expression in islet macrophages started from the neonatal period, well before the occurrence of overt diabetes. Furthermore, the spontaneous development of autoimmune diabetes in NOD mice was markedly reduced by pharmacological inhibition or genetic ablation of FABP4 or adoptive transfer of FABP4-deficient bone marrow cells. Mechanistically, FABP4 activated innate immune responses in islets by enhancing the infiltration and polarization of macrophages to proinflammatory M1 subtype, thus creating an inflammatory milieu required for activation of diabetogenic CD8+ T cells and shift of CD4+ helper T cells toward Th1 subtypes. These findings demonstrate FABP4 as a possible early mediator for β cell autoimmunity by facilitating crosstalk between innate and adaptive immune cells, suggesting that pharmacological inhibition of FABP4 may represent a promising therapeutic strategy for autoimmune diabetes.

PMID:

10.1172/jci.insight.141814

URL link to publication source:

 https://insight.jci.org/articles/view/141814

“Zooming in on Diabetes” is a virtual journal club and was launched in March 2020.

It is a joint initiative across the University of British Columbia campuses including the Life Sciences Centre and the BC Children’s Hospital.

This Journal Club is designed for trainees to develop skills in critical evaluation of recent articles in the scientific literature related to diabetes research.

The intended audience are academic research trainees and faculty involved in diabetes research in British Columbia, Canada.

The journal club is held on Tuesdays and Thursdays via ZOOM.

Apr
22
Thu
Zooming in on Diabetes Journal Club April 22, 2021
Apr 22 @ 9:00 am – 10:00 am

Zooming in on Diabetes Thursday, April 22 at 09:00 am (PST)

Presenter: Mikky Atser, MSc program, Johnson Lab, University of British Columbia (Vancouver)

Title of Paper:  FoxO1 inhibition alleviates type 2 diabetes-related diastolic dysfunction by increasing myocardial pyruvate dehydrogenase activity

Abstract

  Type 2 diabetes (T2D) increases the risk for diabetic cardiomyopathy and is characterized by diastolic dysfunc- tion. Myocardial forkhead box O1 (FoxO1) activity is enhanced in T2D and upregulates pyruvate dehydroge- nase (PDH) kinase 4 expression, which inhibits PDH activity, the rate-limiting enzyme of glucose oxidation. Because low glucose oxidation promotes cardiac inefficiency, we hypothesize that FoxO1 inhibition mitigates diabetic cardiomyopathy by stimulating PDH activity. Tissue Doppler echocardiography demonstrates improved diastolic function, whereas myocardial PDH activity is increased in cardiac-specific FoxO1-deficient mice subjected to experimental T2D. Pharmacological inhibition of FoxO1 with AS1842856 increases glucose oxidation rates in isolated hearts from diabetic C57BL/6J mice while improving diastolic function. However, AS1842856 treatment fails to improve diastolic function in diabetic mice with a cardiac-specific FoxO1 or PDH deficiency. Our work defines a fundamental mechanism by which FoxO1 inhibition improves diastolic dysfunction, suggesting that it may be an approach to alleviate diabetic cardiomyopathy.

URL link to publication source:  https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00249-7

“Zooming in on Diabetes” is a virtual journal club and was launched in March 2020.

It is a joint initiative across the University of British Columbia campuses including the Life Sciences Centre and the BC Children’s Hospital.

This Journal Club is designed for trainees to develop skills in critical evaluation of recent articles in the scientific literature related to diabetes research.

The intended audience are academic research trainees and faculty involved in diabetes research in British Columbia, Canada.

The journal club is held on Tuesdays and Thursdays via ZOOM.

Jun
25
Fri
American Diabetes Association 81st Annual Scientific Sessions 2021
Jun 25 – Jun 29 all day
Sep
28
Tue
European Foundation for the Study of Diabetes Annual Meeting 2021 @ Virtual Meeting
Sep 28 – Oct 1 all day
European Foundation for the Study of Diabetes Annual Meeting 2021 @ Virtual Meeting

#EASD2021

Scientific Programme

Tuesday, 28 September – Friday, 1 October 2021

Abstract Submission

The EASD Abstract Submission System available via MyEASD will close on the deadline 1 April 2021 at 18:00hrs CEST.

 

Nov
12
Fri
Vancouver Diabetes Research Day 2021 @ TBD
Nov 12 all day
Vancouver Diabetes Research Day 2021 @ TBD

 

 

Dec
6
Mon
International Diabetes Federation Congress 2021 Bangkok Thailand @ Bangkok Thailand
Dec 6 – Dec 9 all day

Subscribe To Our Newsletter
Subscribe to our email newsletter today to receive updates on the latest news and goings on.
No Thanks
Thanks for signing up. You must confirm your email address before we can send to you. Please check your email and follow the instructions.
We respect your privacy. Your information is safe and will never be shared.
Don't miss out. Subscribe today.
×
×