Keep up to date with the latest events around the country.
Keep up to date with the latest events around the country.
Zooming in on Diabetes
Tuesday, March 19
12 noon
Zoom presentation
Presenter:
Erin Tanaka, Graduate Student – PhD program, Klein Geltink Lab, BC Women’s and Children’s Hospital
Title:
High-resolution glucose tracing and in situ imaging reveals regulated lactate1 production in human pancreatic β cells
Link to Publication Source:
https://www.biorxiv.org/content/10.1101/2022.12.21.521364v2
Abstract:
Using 13C6 glucose labeling coupled to GC-MS and 2D 1H-13C HSQC NMR spectroscopy, we have obtained a comparative high-resolution map of glucose fate underpinning β cell function. In both mouse and human islets, the contribution of glucose to the TCA cycle is similar. Pyruvate-fueling of the TCA cycle is primarily mediated by the activity of pyruvate dehydrogenase, with lower flux through pyruvate carboxylase. While conversion of pyruvate to lactate by lactate dehydrogenase (LDH) can be detected in islets of both species, lactate accumulation is six-fold higher in human islets. Human islets express LDH, with low-moderate LDHA expression and β cell-specific LDHB expression. LDHB inhibition increases glucose-dependent lactate generation in mouse and human β cells, and decreases Ca2+-spiking frequency without affecting ATP/ADP levels. Thus, we show that LDHB limits glucose-stimulated lactate generation in β cells. Further studies are warranted to understand how lactate impacts β cell metabolism and/or function.
About Zooming in on Diabetes Journal Club
It is a joint initiative across the University of British Columbia campuses including the Life Sciences Centre and the BC Children’s Hospital.
This Journal Club is designed for trainees to develop skills in critical evaluation of recent articles in the scientific literature related to diabetes research.
The intended audience are academic research trainees and faculty involved in diabetes research in British Columbia, Canada.
The journal club is held on Tuesdays and Thursdays via ZOOM.
Zooming in on Diabetes
Thursday, March 21
09:00 am
Zoom Presentation
Presenter:
Hayley Reeves, Graduate Student – PhD program, Rideout Lab, Life Sciences Institute, University of British Columbia (Vancouver)
Title of Paper:
Investigating the Role of 17-Beta Estradiol in the Regulation of the Unfolded Protein Response (UPR) in Pancreatic Beta Cells
URL link to publication source:
https://www.mdpi.com/1422-0067/25/3/1816
Abstract:
Diabetes mellitus is clinically defined by chronic hyperglycemia. Sex differences in the presentation and outcome of diabetes exist with premenopausal women having a reduced risk of developing diabetes, relative to men, or women after menopause. Accumulating evidence shows a protective role of estrogens, specifically 17-beta estradiol, in the maintenance of pancreatic beta cell health; however, the mechanisms underlying this protection are still unknown. To elucidate these potential mechanisms, we used a pancreatic beta cell line (BTC6) and a mouse model of hyperglycemia-induced atherosclerosis, the ApoE−/−:Ins2+/Akita mouse, exhibiting sexual dimorphism in glucose regulation. In this study we hypothesize that 17-beta estradiol protects pancreatic beta cells by modulating the unfolded protein response (UPR) in response to endoplasmic reticulum (ER) stress. We observed that ovariectomized female and male ApoE−/−:Ins2+/Akita mice show significantly increased expression of apoptotic UPR markers. Sham operated female and ovariectomized female ApoE−/−:Ins2+/Akita mice supplemented with exogenous 17-beta estradiol increased the expression of adaptive UPR markers compared to non-supplemented ovariectomized female ApoE−/−:Ins2+/Akita mice. These findings were consistent to what was observed in cultured BTC6 cells, suggesting that 17-beta estradiol may protect pancreatic beta cells by repressing the apoptotic UPR and enhancing the adaptive UPR activation in response to pancreatic ER stress.
PMID:
38339098
Endocrine Research Society
23rd annual
BC Endocrine Day
May 10th, 2024 | 8 AM – 4 PM Vancouver Holiday-Inn Centre (Broadway)
The Endocrine Research Society is pleased to present an interactive case-based review of endocrine problems encountered in clinical office practice.
Early Bird | Until March 15th, 2024 | $225
Regular | After March 15th, 2024 | $275 Non-Endocrinology Trainees | Until March 15, 2024 | $90 Non-Endocrinology Trainees | After March 15th, 2024 | $100 VGH & SPH Endocrinology Trainees | FREE
www.endocrineresearchsociety.com/conferences
SAVE THE DATE: June 4th Visiting Scientist Seminar “Designing vascularized tissue models and devices for diabetes cellular therapy”
UBC/BCCHR will be hosting a special visiting scientist seminar in June.
Dr Corinne Hoesli is the Canada Rsearch Chair in Cellular Tissue Bioprocess Engineering at McGill University.
She will be giving a seminar on Tuesday, June 4th in our regular Tuesday diabetes journal club 12:00-13:00 time slot.
UBC Okanagan
DIABETES & OBESITY RESEARCH DAY 2024
Academic Research Conference
June 12, 2024
Kelowna, British Columbia
Meeting Website: https://event.fourwaves.com/dord2024/pages
Key Dates:
May 12 – Abstract Submission Deadline (1 month before event)
May 28 – Registration Deadline (2 weeks before event)
May 12 – Ground Transportation & Accommodation Deadline (1 month before event)
Keynote Speaker:
Raylene Reimer, PhD, RD
Professor of Nutrition, Faculty of Kinesiology, University of Calgary
Invited Faculty Speakers:
Daniel Gamu, PhD, Assistant Professor in Exercise, Metabolism, Nutrition & Health, School of Kinesiology, UBC Vancouver
Hashim Islam, PhD, Assistant Professor, School of Health & Exercise Sciences, Centre for Chronic Disease Prevention & Management, UBC Okanagan