Calendar

Keep up to date with the latest events around the country.

Sep
21
Tue
Zooming in on Diabetes Journal Club September 21, 2021
Sep 21 @ 12:00 pm – 1:00 pm

Zooming in on Diabetes September 21 at 12:00 (PST)

Presenter: Jocelyn Begin, Graduate Student – MSc program, Hoffman Lab, University of British Columbia (Vancouver)

Title of Paper: Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity

Citation  Nature Metabolism volume 3, pages 1042–1057 (2021)

Abstract:

Obesity and its consequences are among the greatest challenges in healthcare. The gut microbiome is recognized as a key factor in the pathogenesis of obesity. Using a mouse model, we show here that a wild-derived microbiome protects against excessive weight gain, severe fatty liver disease and metabolic syndrome during a 10-week course of high-fat diet. This phenotype is transferable only during the first weeks of life. In adult mice, neither transfer nor severe disturbance of the wild-type microbiome modifies the metabolic response to a high-fat diet. The protective phenotype is associated with increased secretion of metabolic hormones and increased energy expenditure through activation of brown adipose tissue. Thus, we identify a microbiome that protects against weight gain and its negative consequences through metabolic programming in early life. Translation of these results to humans may identify early-life therapeutics that protect against obesity.

URL link to publication source: https://doi.org/10.1038/s42255-021-00439-y

 

“Zooming in on Diabetes” is a virtual journal club and was launched in March 2020.

It is a joint initiative across the University of British Columbia campuses including the Life Sciences Centre and the BC Children’s Hospital.

This Journal Club is designed for trainees to develop skills in critical evaluation of recent articles in the scientific literature related to diabetes research.

The intended audience are academic research trainees and faculty involved in diabetes research in British Columbia, Canada.

The journal club is held on Tuesdays and Thursdays via ZOOM.

Sep
23
Thu
Zooming in on Diabetes Journal Club September 23, 2021
Sep 23 @ 9:00 am – 10:00 am

Zooming in on Diabetes Journal Club 

Thursday, September 23 at 09:00 (PST)

Presenter: Aurora Mattison, Graduate Student – PhD program, University of British Columbia (Vancouver)

Title of Paper:

Loss of Secretory Pathway Ca2+ ATPase (SPCA1) Impairs Insulin Secretion and Reduces Autophagy in the Pancreatic Islet

Abstract:

The β cell Golgi apparatus serves as a significant store of intracellular Ca2+ and an important site of proinsulin maturation. However, the contribution of Golgi Ca2+ to diabetes pathophysiology is unknown. The Golgi primarily utilizes the Secretory Pathway Ca2+ ATPase (SPCA1) to maintain intraluminal Ca2+ stores, and loss of SPCA1 has been linked to impaired Golgi function in other cell types. Here, we demonstrated that SPCA1 expression is decreased in islets from diabetic mice and human organ donors with type 2 diabetes, suggesting SPCA1 may impact diabetes development. INS-1 β cells lacking SPCA1 (SPCA1KO) showed reduced intraluminal Golgi Ca2+ levels, reduced glucose-stimulated insulin secretion (GSIS), and increased insulin content. Islets from SPCA1 haploinsufficient mice (SPCA1+/-) exhibited reduced GSIS, altered glucose-induced Ca2+ oscillations, and altered insulin granule maturation. Autophagy can regulate granule homeostasis, therefore we induced autophagy with Torin1 and found that SPCA1KO cells and SPCA1+/- islets had reduced levels of the autophagosome marker LC3-II. Furthermore, SPCA1KO LC3-II were unchanged after blocking autophagy initiation or autophagolysosome fusion and acidification. Thus, we concluded that β cell SPCA1 plays an important role in the maintenance of Golgi Ca2+ homeostasis and reduced Golgi Ca2+ impairs autophagy initiation and may impact insulin granule homeostasis.

URL link to publication source: https://www.biorxiv.org/content/10.1101/2021.08.30.458203v1.full

 

“Zooming in on Diabetes” is a virtual journal club and was launched in March 2020.

It is a joint initiative across the University of British Columbia campuses including the Life Sciences Centre and the BC Children’s Hospital.

This Journal Club is designed for trainees to develop skills in critical evaluation of recent articles in the scientific literature related to diabetes research.

The intended audience are academic research trainees and faculty involved in diabetes research in British Columbia, Canada.

The journal club is held on Tuesdays and Thursdays via ZOOM.

Sep
28
Tue
European Foundation for the Study of Diabetes Annual Meeting 2021 @ Virtual Meeting
Sep 28 – Oct 1 all day
European Foundation for the Study of Diabetes Annual Meeting 2021 @ Virtual Meeting

#EASD2021

Scientific Programme

Tuesday, 28 September – Friday, 1 October 2021

Abstract Submission

The EASD Abstract Submission System available via MyEASD will close on the deadline 1 April 2021 at 18:00hrs CEST.

 

Sep
30
Thu
Orange Shirt Day
Sep 30 all day
Orange Shirt Day

September 30 is Orange Shirt Day

As UBC commemorates our National Day of Truth and Reconciliation, learn about the history of Orange Shirt Day and residential schools and find support resources.

 

 

 

Oct
2
Sat
Diabetes Canada Know No Limits with T1D Conference @ virtual event
Oct 2 @ 11:00 am – 7:00 pm
Oct
22
Fri
Endocrine Research Society 33rd Annual Diabetes Directors Seminar @ Zoom Video Conference
Oct 22 all day

Endocrine Research Society 33rd Annual Diabetes Directors Seminar

Vancouver- Friday, October 22nd, 2021

 

The Endocrine Research Society is pleased to present the 33rd Diabetes Directors Seminar – an annual, CFPC and RCPSC-accredited gathering of leading diabetes experts and caregivers across British Columbia.

Join us virtually from home or work over Zoom Video conferencing for a full day presentation series covering the latest and most pertinent aspects of diabetes therapeutics and clinical care. 

Target Audience: Specialists and family physicians with an interest in diabetes care, as well as nurses, dieticians, pharmacists and other diabetes educators responsible for diabetes management within their own groups and communities.

 

Register now as space is limited.

Online registration can be found at the following link:https://www.endocrineresearchsociety.com/events/33rd-annual-diabetes-directors-seminar

 

Please contact Calvin Chang at the Endocrine Research Society for more information or registration questions.
Email: [email protected]
Phone: (604) 689-1055
Nov
12
Fri
Vancouver Diabetes Research Day 2021 @ Vitrual Online Event
Nov 12 all day
Vancouver Diabetes Research Day 2021 @ Vitrual Online Event

 

 

Dec
6
Mon
International Diabetes Federation Congress 2021 Bangkok Thailand @ Bangkok Thailand
Dec 6 – Dec 9 all day

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