Calendar

Keep up to date with the latest events around the country.

Oct
20
Tue
Zooming in on Diabetes Journal Club October 20
Oct 20 @ 12:00 pm – 1:00 pm

Zooming in on Diabetes  Tuesday October 20 at 12:00 pm (PST)

Presenter:

Marcus Woodley, Graduate Student – PhD program, Lynn Lab, BC Women’s and Children’s Hospital, University of British Columbia (Vancouver)

Title of Paper:  

Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19- Positive b Cell Destruction

Abstract:

Autoimmune destruction of pancreatic β cells underlies type 1 diabetes (T1D). To understand T cell-mediated immune effects on human pancreatic β cells, we combine β cell-specific expression of a model antigen, CD19, and anti-CD19 chimeric antigen receptor T (CAR-T) cells. Coculturing CD19-expressing β-like cells and CD19 CAR-T cells results in T cell-mediated β-like cell death with release of activated T cell cytokines. Transcriptome analysis of β-like cells and human islets treated with conditioned medium of the immune reaction identifies upregulation of immune reaction genes and the pyroptosis mediator GSDMD as well as its activator CASP4. Caspase-4-mediated cleaved GSDMD is detected in β-like cells under inflammation and endoplasmic reticulum (ER) stress conditions. Among immune-regulatory genes, PDL1 is one of the most upregulated, and PDL1 overexpression partially protects human β-like cells transplanted into mice. This experimental platform identifies potential mechanisms of β cell destruction and may allow testing of therapeutic strategies.

Authors: 

Haiting Ma, Jacob F. Jeppesen, Rudolf Jaenisch

URL link to publication source:

Cell Reports Medicine, Volume 1, Issue 6, 2020, 100097, ISSN 2666-3791,

 https://www.sciencedirect.com/science/article/pii/S2666379120301233

 

“Zooming in on Diabetes” is a virtual journal club and was launched in March 2020.

It is a joint initiative across the University of British Columbia campuses including the Life Sciences Centre and the BC Children’s Hospital.

This Journal Club is designed for trainees to develop skills in critical evaluation of recent articles in the scientific literature related to diabetes research.

The intended audience are academic research trainees and faculty involved in diabetes research in British Columbia, Canada.

The journal club is held on Tuesdays and Thursdays via ZOOM.

Oct
23
Fri
Endocrine Research Society’s 32nd Annual Diabetes Directors Seminar @ Zoom Videoconference
Oct 23 all day
Endocrine Research Society's 32nd Annual Diabetes Directors Seminar @ Zoom Videoconference

The 32nd Annual Diabetes Directors Seminar

Friday, October 23rd 2020

 

The Endocrine Research Society is pleased to present the 32nd Diabetes Directors Seminar – an annual, CFPC and RCPSC-accredited gathering of leading diabetes experts and caregivers across British Columbia.

 

Join us virtually from home or work over Zoom Videoconferencing for a full day presentation series covering the latest and most pertinent aspects of diabetes therapeutics and clinical care.

 

Target Audience: Specialists and family physicians with an interest in diabetes care, as well as nurses, dieticians, pharmacists and other diabetes educators responsible for diabetes management within their own groups and communities.

 

Register now as space is limited.

https://www.endocrineresearchsociety.com/events/32nd-annual-diabetes-directors-seminar2

 

 

Oct
28
Wed
Diabetes Canada/Canadian Society of Endocrinology and Metabolism Professional Conference 2020 @ Virtual Meeting
Oct 28 – Oct 30 all day
Diabetes Canada/Canadian Society of Endocrinology and Metabolism Professional Conference 2020 @ Virtual Meeting

Diabetes Canada/Canadian Society of Endocrinology and Metabolism Professional Conference presents “Reaching New Heights”.

Nov
13
Fri
Vancouver Diabetes Research Day 2020
Nov 13 @ 8:30 am – 4:30 pm
Nov
18
Wed
Clee Symposium 2020
Nov 18 @ 1:00 pm – 4:00 pm
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