Calendar

Keep up to date with the latest events around the country.

Aug
13
Thu
Zooming in on Diabetes Journal Club August 13
Aug 13 @ 9:00 am – 10:00 am

Zooming in on Diabetes Journal Club August 13, 2020

Presenter: Dr Evgeniy Panzhinskiy, Post-Doctoral Fellow, Johnson Laboratory, UBC Life Sciences Institute

Title: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

Citation: Yang et al., 2020, Cell Stem Cell 27, 125–136

 

Abstract:

SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for physiological models to study SARS-CoV-2 infection using human disease-relevant cells. COVID-19 pathophysiology includes respiratory failure but involves other organ systems including gut, liver, heart, and pancreas. We present an experimental platform comprised of cell and organoid derivatives from human pluripotent stem cells (hPSCs). A Spike-enabled pseudo-entry virus infects pancreatic endocrine cells, liver organoids, cardiomyocytes, and dopaminergic neurons. Recent clinical studies show a strong association with COVID-19 and diabetes. We find that human pancreatic beta cells and liver organoids are highly permissive to SARS-CoV-2 infection, further validated using adult primary human islets and adult hepatocyte and cholangiocyte organoids. SARS-CoV-2 infection caused striking expression of chemokines, as also seen in primary human COVID-19 pulmonary autopsy samples. hPSC-derived cells/organoids provide valuable models for understanding the cellular responses of human tissues to SARS-CoV-2 infection and for disease modeling of COVID-19.

PMID: 32579880

URL: https://doi.org/10.1016/j.stem.2020.06.015

 

“Zooming in on Diabetes” is a virtual Journal Club/Work in Progress series and was launched in March 2020.

It is a joint initiative across the University of British Columbia’s campuses including the Life Sciences Institute and the BC Children’s Hospital.

The series is designed for trainees to develop presentation skills and practice critical evaluation of recent articles in the scientific literature related to diabetes research.

The intended audience are academic research trainees and faculty involved in diabetes research.

The journal club is held on Tuesdays and Thursdays via ZOOM.

Aug
27
Thu
Zooming in on Diabetes Journal Club August 27
Aug 27 @ 9:00 am – 10:00 am

Zooming in on Diabetes Journal Club August 27, 2020

Presenter: Aurora Mattison, Masters Program, Johnson Lab, UBC Life Sciences Institute

 
Dietary carbohydrates modulate metabolic and β-cell adaptation to high-fat diet-induced obesity

Authors: Tracy K. Her1* William S. Lagakos,1 * Matthew R. Brown,1 Nathan K. LeBrasseur,2 Kuntol Rakshit,1 and Aleksey V. Matveyenko1,3 

1 Department of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, Minnesota; 

2 Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota; 

3 Department of Medicine, Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Mayo Clinic School of Medicine, Rochester, Minnesota

 
Abstract 
Obesity is associated with several chronic comorbidities, one of which is type 2 diabetes mellitus (T2DM). The pathogenesis of obesity and T2DM is influenced by alterations in diet macronutrient composition, which regulate energy expenditure, metabolic function, glucose homeostasis, and pancreatic islet cell biology. Recent studies suggest that increased intake of dietary carbohydrates plays a previously underappreciated role in the promotion of obesity and consequent metabolic dysfunction. Thus, in this study, we utilized mouse models to test the hypothesis that dietary carbohydrates modulate energetic, metabolic, and islet adaptions to high-fat diets. To address this, we exposed C57BL/6J mice to 12 wk of 3 eucaloric high-fat diets (60% calories from fat) with varying total carbohydrate (1–20%) and sucrose (0 –20%) content. Our results show that severe restriction of dietary carbohydrates characteristic of ketogenic diets reduces body fat accumulation, enhances energy expenditure, and reduces prevailing glycemia and insulin resistance compared with carbohydrate-rich, high-fat diets. Moreover, severe restriction of dietary carbohydrates also results in functional, morphological, and molecular changes in pancreatic islets highlighted by restricted capacity for -cell mass expansion and alterations in insulin secretory response. These studies support the hypothesis that lowcarbohydrate/high-fat diets provide antiobesogenic benefits and suggest further evaluation of the effects of these diets on -cell biology in humans

 PMID: 32315211

“Zooming in on Diabetes” is a virtual Journal Club/Work in Progress series and was launched in March 2020.

It is a joint initiative across the University of British Columbia’s campuses including the Life Sciences Centre and the BC Children’s Hospital.

The series is designed for trainees to develop presentation skills and practice critical evaluation of recent articles in the scientific literature related to diabetes research.

The intended audience are academic research trainees and faculty involved in diabetes research.

The journal club is held on Tuesdays and Thursdays via ZOOM.

Sep
21
Mon
European Foundation for the Study of Diabetes Annual Meeting 2020 @ Virtual Meeting
Sep 21 – Sep 25 all day
Oct
7
Wed
2020 Saltin International Graduate Webinar in Exercise and Clinical Physiology: Foundations to Frontiers @ UBC School of Kinesiology
Oct 7 @ 10:00 am – 2:15 pm

The 2020 Saltin International Graduate Webinar in Exercise and Clinical Physiology: Foundations to Frontiers

This event will be held virtually as a webinar.

Registration opens on Tuesday, September 8, 2020. 

Oct
8
Thu
2020 Saltin International Graduate Webinar in Exercise and Clinical Physiology: Foundations to Frontiers @ UBC School of Kinesiology
Oct 8 @ 10:00 am – 2:15 pm

The 2020 Saltin International Graduate Webinar in Exercise and Clinical Physiology: Foundations to Frontiers

This event will be held virtually as a webinar.

Registration opens on Tuesday, September 8, 2020. 

Oct
15
Thu
Canadian Vascular & Lipid Summit 2020 @ Virtual Event
Oct 15 – Oct 18 all day
Oct
28
Wed
Diabetes Canada/Canadian Society of Endocrinology and Metabolism Professional Conference 2020 @ Virtual Meeting
Oct 28 – Oct 30 all day
Diabetes Canada/Canadian Society of Endocrinology and Metabolism Professional Conference 2020 @ Virtual Meeting

Diabetes Canada/Canadian Society of Endocrinology and Metabolism Professional Conference presents “Reaching New Heights”.

Nov
13
Fri
Vancouver Diabetes Research Day 2020
Nov 13 @ 8:30 am – 4:30 pm
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