Calendar

Keep up to date with the latest events around the country.

Mar
19
Tue
Zooming in on Diabetes Journal Club March 19
Mar 19 @ 12:00 pm – 1:00 pm

Zooming in on Diabetes 

Tuesday, March 19

12 noon

Zoom presentation

Presenter:

Erin Tanaka, Graduate Student – PhD program, Klein Geltink Lab, BC Women’s and Children’s Hospital

Title:

High-resolution glucose tracing and in situ imaging reveals regulated lactate1 production in human pancreatic β cells

Link to Publication Source:

https://www.biorxiv.org/content/10.1101/2022.12.21.521364v2

Abstract:

Using 13C6 glucose labeling coupled to GC-MS and 2D 1H-13C HSQC NMR spectroscopy, we have obtained a comparative high-resolution map of glucose fate underpinning β cell function. In both mouse and human islets, the contribution of glucose to the TCA cycle is similar. Pyruvate-fueling of the TCA cycle is primarily mediated by the activity of pyruvate dehydrogenase, with lower flux through pyruvate carboxylase. While conversion of pyruvate to lactate by lactate dehydrogenase (LDH) can be detected in islets of both species, lactate accumulation is six-fold higher in human islets. Human islets express LDH, with low-moderate LDHA expression and β cell-specific LDHB expression. LDHB inhibition increases glucose-dependent lactate generation in mouse and human β cells, and decreases Ca2+-spiking frequency without affecting ATP/ADP levels. Thus, we show that LDHB limits glucose-stimulated lactate generation in β cells. Further studies are warranted to understand how lactate impacts β cell metabolism and/or function.

 

About Zooming in on Diabetes Journal Club

It is a joint initiative across the University of British Columbia campuses including the Life Sciences Centre and the BC Children’s Hospital.

This Journal Club is designed for trainees to develop skills in critical evaluation of recent articles in the scientific literature related to diabetes research.

The intended audience are academic research trainees and faculty involved in diabetes research in British Columbia, Canada.

The journal club is held on Tuesdays and Thursdays via ZOOM.

Mar
21
Thu
Zooming in on Diabetes Virtual Journal Club March 21
Mar 21 @ 9:00 am – 10:00 am

Zooming in on Diabetes

Thursday, March 21

09:00 am

Zoom Presentation

Presenter:

Hayley Reeves, Graduate Student – PhD program, Rideout Lab, Life Sciences Institute, University of British Columbia (Vancouver)

 

Title of Paper:

Investigating the Role of 17-Beta Estradiol in the Regulation of the Unfolded Protein Response (UPR) in Pancreatic Beta Cells

URL link to publication source:

https://www.mdpi.com/1422-0067/25/3/1816

Abstract:

Diabetes mellitus is clinically defined by chronic hyperglycemia. Sex differences in the presentation and outcome of diabetes exist with premenopausal women having a reduced risk of developing diabetes, relative to men, or women after menopause. Accumulating evidence shows a protective role of estrogens, specifically 17-beta estradiol, in the maintenance of pancreatic beta cell health; however, the mechanisms underlying this protection are still unknown. To elucidate these potential mechanisms, we used a pancreatic beta cell line (BTC6) and a mouse model of hyperglycemia-induced atherosclerosis, the ApoE−/−:Ins2+/Akita mouse, exhibiting sexual dimorphism in glucose regulation. In this study we hypothesize that 17-beta estradiol protects pancreatic beta cells by modulating the unfolded protein response (UPR) in response to endoplasmic reticulum (ER) stress. We observed that ovariectomized female and male ApoE−/−:Ins2+/Akita mice show significantly increased expression of apoptotic UPR markers. Sham operated female and ovariectomized female ApoE−/−:Ins2+/Akita mice supplemented with exogenous 17-beta estradiol increased the expression of adaptive UPR markers compared to non-supplemented ovariectomized female ApoE−/−:Ins2+/Akita mice. These findings were consistent to what was observed in cultured BTC6 cells, suggesting that 17-beta estradiol may protect pancreatic beta cells by repressing the apoptotic UPR and enhancing the adaptive UPR activation in response to pancreatic ER stress.

PMID:

38339098

May
24
Fri
BC Endocrine Day 2024 @ Holiday Inn Centre
May 24 @ 8:00 am – 4:30 pm
BC Endocrine Day 2024 @ Holiday Inn Centre

Endocrine Research Society

23rd annual

BC Endocrine Day

May 10th, 2024 | 8 AM – 4 PM Vancouver Holiday-Inn Centre (Broadway)

The Endocrine Research Society is pleased to present an interactive case-based review of endocrine problems encountered in clinical office practice.

Early Bird | Until March 15th, 2024 | $225
Regular | After March 15th, 2024 | $275 Non-Endocrinology Trainees | Until March 15, 2024 | $90 Non-Endocrinology Trainees | After March 15th, 2024 | $100 VGH & SPH Endocrinology Trainees | FREE

www.endocrineresearchsociety.com/conferences

Jun
4
Tue
Visiting Scientist Seminar: Dr Corinne Hoesli
Jun 4 @ 12:00 pm – 1:00 pm
Visiting Scientist Seminar: Dr Corinne Hoesli

SAVE THE DATE: June 4th Visiting Scientist Seminar “Designing vascularized tissue models and devices for diabetes cellular therapy”

 UBC/BCCHR will be hosting a special visiting scientist seminar in June.  

Dr Corinne Hoesli is the Canada Rsearch Chair in Cellular Tissue Bioprocess Engineering at McGill University.

She will be giving a seminar on Tuesday, June 4th in our regular Tuesday diabetes journal club 12:00-13:00 time slot.

 

Jun
12
Wed
DIABETES & OBESITY RESEARCH DAY 2024 @ Reichwald Health Sciences Centre
Jun 12 all day
DIABETES & OBESITY RESEARCH DAY 2024 @ Reichwald Health Sciences Centre

UBC Okanagan 

DIABETES & OBESITY RESEARCH DAY 2024

Academic Research Conference

June 12, 2024

Kelowna, British Columbia

 

Meeting Website: https://event.fourwaves.com/dord2024/pages 

 

Key Dates:

May 12 – Abstract Submission Deadline (1 month before event)

May 28 – Registration Deadline (2 weeks before event)

May 12 – Ground Transportation & Accommodation Deadline (1 month before event)

 

Keynote Speaker:

Raylene Reimer, PhD, RD

Professor of Nutrition, Faculty of Kinesiology, University of Calgary

 

Invited Faculty Speakers:

Daniel Gamu, PhD, Assistant Professor in Exercise, Metabolism, Nutrition & Health, School of Kinesiology, UBC Vancouver

Hashim Islam, PhD, Assistant Professor, School of Health & Exercise Sciences, Centre for Chronic Disease Prevention & Management, UBC Okanagan

 

Nov
14
Thu
VANCOUVER DIABETES RESEARCH DAY 2024 @ University of British Columbia
Nov 14 all day
Feb
11
Tue
ALBERTA-BRITISH COLUMBIA ISLET WORKSHOP 2025 @ Silver Star Mountain
Feb 11 – Feb 14 all day
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