Zooming in on Diabetes Journal Club June 9

Zooming in on Diabetes Journal Club June 9

When:
June 9, 2020 @ 12:00 pm – 1:00 pm
2020-06-09T12:00:00-07:00
2020-06-09T13:00:00-07:00
Where:
ZOOM
Cost:
Free
Contact:
BC Diabetes Research Network

Journal Article: Effect of different levels of dietary methionine restriction on relieving oxidative stress and behavioral deficits in middle-aged mice fed low-, medium-, or high-fat diet

Presenter: Yuka Obayashi, PhD Program

Hoffman Lab, BC Children’s Hospital Research Institute

Abstract:
Dietary methionine restriction (MR) could prevent age-related diseases and extend lifespan. The present study compared the effects of different levels of MR on oxidative stress and behavioral deficits in middle-aged mice fed a diet with various contents of fat. C57BL/6J middle-aged male mice were divided into nine groups with various combinations of dietary fat (low, medium, and high) and MR (0%, 60%, and 80%). MR attenuated dietary fat-induced oxidative stress and anxiety; improved athletic ability, learning, memory, and cognitive ability in conjunction with an improved thyroid function in a dose-dependent manner. Moreover, the beneficial effect of MR60 was prominent in middle-aged mice fed a HF diet relative to the corresponding MR0 group. These results provide more information on the appropriate methionine content to design personalized nutritional diets.

 

“Zooming in on Diabetes” is a virtual journal club and was launched in March 2020.

It is a joint initiative across the University of British Columbia campuses including the Life Sciences Centre and the BC Children’s Hospital.

This Journal Club is designed for trainees to develop skills in critical evaluation of recent articles in the scientific literature related to diabetes research.

The intended audience are academic research trainees and faculty involved in diabetes research.

The journal club is held on Tuesdays and Thursdays via ZOOM.

Subscribe To Our Newsletter
Subscribe to our email newsletter today to receive updates on the latest news and goings on.
No Thanks
Thanks for signing up. You must confirm your email address before we can send to you. Please check your email and follow the instructions.
We respect your privacy. Your information is safe and will never be shared.
Don't miss out. Subscribe today.
×
×