Zooming in on Diabetes Journal Club June 9
Presenter: Yuka Obayashi, PhD Program
Hoffman Lab, BC Children’s Hospital Research Institute
Abstract:
Dietary methionine restriction (MR) could prevent age-related diseases and extend lifespan. The present study compared the effects of different levels of MR on oxidative stress and behavioral deficits in middle-aged mice fed a diet with various contents of fat. C57BL/6J middle-aged male mice were divided into nine groups with various combinations of dietary fat (low, medium, and high) and MR (0%, 60%, and 80%). MR attenuated dietary fat-induced oxidative stress and anxiety; improved athletic ability, learning, memory, and cognitive ability in conjunction with an improved thyroid function in a dose-dependent manner. Moreover, the beneficial effect of MR60 was prominent in middle-aged mice fed a HF diet relative to the corresponding MR0 group. These results provide more information on the appropriate methionine content to design personalized nutritional diets.
“Zooming in on Diabetes” is a virtual journal club and was launched in March 2020.
It is a joint initiative across the University of British Columbia campuses including the Life Sciences Centre and the BC Children’s Hospital.
This Journal Club is designed for trainees to develop skills in critical evaluation of recent articles in the scientific literature related to diabetes research.
The intended audience are academic research trainees and faculty involved in diabetes research.
The journal club is held on Tuesdays and Thursdays via ZOOM.