Zooming in on Diabetes Journal Club May 19, 2022

Zooming in on Diabetes Journal Club May 19, 2022

When:
May 19, 2022 @ 9:00 am – 10:00 am
2022-05-19T09:00:00-07:00
2022-05-19T10:00:00-07:00
Where:
ZOOM
Cost:
Free
Contact:
BC Diabetes Research Network

Zooming in on Diabetes

Thursday, May 19 at 09:00 

Presenter:

Dr. Jelena Kolic, Post-Doctoral Fellow, Johnson Lab, Life Sciences Institute, University of British Columbia (Vancouver)

Title of Paper:

Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice

Abstract:

Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome associated with energy harvest alters dramatically in response to nutrient deprivation. Here, we reported that CR and high-fat diet (HFD) both remodeled the gut microbiota with similar microbial composition, Parabacteroides distasonis was most significantly decreased after CR or HFD. CR altered microbiota and reprogramed metabolism, resulting in a distinct serum bile acid profile characterized by depleting the proportion of non-12α-hydroxylated bile acids, ursodeoxycholic acid and lithocholic acid. Downregulation of UCP1 expression in brown adipose tissue and decreased serum GLP-1 were observed in the weight-rebound mice. Moreover, treatment with Parabacteroides distasonis or non-12α-hydroxylated bile acids ameliorated weight regain via increased thermogenesis. Our results highlighted the gut microbiota-bile acid crosstalk in rebound weight gain and Parabacteroides distasonis as a potential probiotic to prevent rapid post-CR weight gain.

PMID: 

35440584

URL link to publication source:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018700/

About Zooming in on Diabetes Journal Club

It is a joint initiative across the University of British Columbia campuses including the Life Sciences Centre and the BC Children’s Hospital.

This Journal Club is designed for trainees to develop skills in critical evaluation of recent articles in the scientific literature related to diabetes research.

The intended audience are academic research trainees and faculty involved in diabetes research in British Columbia, Canada.

The journal club is held on Tuesdays and Thursdays via ZOOM.

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