Zooming in on Diabetes Journal Club January 20, 2022
Zooming in on Diabetes January 20, 2022 at 09:00 (PST)
Dr. Liam Hall, Post-Doctoral Fellow, Johnson Lab, Life Sciences Institute, University of British Columbia
Title: Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis
Citation: Sato S, Dyar K, Treebak JT, Linde Basse A, Schönke M, Chen S, et al. Atlas of Exercise Metabolism Reveals Time-Dependent Signatures of Metabolic Homeostasis. Available at SSRN 3707270.
Abstract:
Tissue sensitivity and response to exercise vary according to the time of day and alignment of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not fully defined. To understand how tissues independently and collectively respond to timed exercise, we applied a systems biology approach. We mapped and compared global metabolite responses of seven different mouse tissues and serum after an acute exercise bout performed at different times of the day. Comparative analyses of intra- and inter-tissue metabolite dynamics, including temporal profiling and blood sampling across liver and hindlimb muscles, uncovered an unbiased view of local and systemic metabolic responses to exercise unique to time of day. This comprehensive atlas of exercise metabolism provides clarity and physiological context regarding the production and distribution of canonical and novel time-dependent exerkine metabolites, such as 2-hydroxybutyrate (2-HB), and reveals insight into the health-promoting benefits of exercise on metabolism.
URL link to publication source:
https://www.sciencedirect.com/science/article/pii/S1550413121006355?via%3Dihub
“Zooming in on Diabetes” is a virtual journal club and was launched in March 2020.
It is a joint initiative across the University of British Columbia campuses including the Life Sciences Centre and the BC Children’s Hospital.
This Journal Club is designed for trainees to develop skills in critical evaluation of recent articles in the scientific literature related to diabetes research.
The intended audience are academic research trainees and faculty involved in diabetes research in British Columbia, Canada.
The journal club is held on Tuesdays and Thursdays via ZOOM.
